H2N2V1, Main, Exploration, bibRecord, 002693

Effect of influenza viras on phagocytic cells

Identifieur interne : 002693 ( Main/Exploration ); précédent : 002692; suivant : 002694

Effect of influenza viras on phagocytic cells

Auteurs : Y. Debets-Ossenkopp [Pays-Bas] ; E. L. Mills [Pays-Bas] ; W. C. Van Dijk [Pays-Bas] ; H. A. Verbrugh [Pays-Bas] ; J. Verhoef [Pays-Bas]

Source :

European Journal of Clinical Microbiology [ 0722-2211 ] ; 1982-06-01.

RBID : ISTEX:09BC710D957C6B17EB7C06F54AF9D98180C0B69F

Descripteurs français

KwdFr :
- Activité bactéricide du sang, Chimiotaxie des leucocytes, Granulocytes neutrophiles (immunologie), Humains, Mesures de luminescence, Phagocytes (immunologie), Phagocytose, Réplication virale, Survie cellulaire, Virus de la grippe A (immunologie).
MESH :
- immunologie : Granulocytes neutrophiles, Phagocytes, Virus de la grippe A.
- Activité bactéricide du sang, Chimiotaxie des leucocytes, Humains, Mesures de luminescence, Phagocytose, Réplication virale, Survie cellulaire.

English descriptors

KwdEn :
- Blood Bactericidal Activity, Cell Survival, Chemotaxis, Leukocyte, Humans, Influenza A virus (immunology), Luminescent Measurements, Neutrophils (immunology), Phagocytes (immunology), Phagocytosis, Virus Replication.
MESH :
- immunology : Influenza A virus, Neutrophils, Phagocytes.
Teeft :
- Additional virus, Alveolar macrophages, Blood Bactericidal Activity, Cell Survival, Chemiluminescence, Chemotaxis, Chemotaxis, Leukocyte, Control pmns, Humans, Influenza, Influenza infection, Influenza virus, Influenza virus particles, Influenza viruses, Leukocyte, Luminescent Measurements, Macrophage, Neuraminidase, Neutrophil, Phagocytic, Phagocytic cells, Phagocytic function, Phagocytosis, Pmns, Polymorphonuclear, Polymorphonuclear leukocytes, Staphylococcus aureus, Various concentrations, Vial, Virus, Virus Replication, Virus particles, Virus suspension, Virus treatment, Water bath.

Abstract

Abstract: Many viral infections predispose to bacterial superinfection, and it has been suggested that the increased susceptibility to bacterial infections is at least in part due to the effect of virus on the phagocytic cell function. Since the mechanisms by which the viruses affect neutrophil function are not well understood, we studied the function of polymorphonuclear leukocytes (PMNs) after incubation with influenza virus. Phagocytosis was assayed by incubating influenza virus (strain type A-Texas-77 [H2N2]) treated leukocytes with3H-thymidine-labelled staphylococci. The oxidative metabolism of the PMNs was studied by measuring the chemiluminescence generated by virus-treated PMNs after incubation with zymosan. Chemotaxis was measured under agarose. After incubation with 107 EID50 units of influenza virus, PMNs ingested only 35 % of the bacteria, whereas control leukocytes ingested over 80 %. Influenza virus also reduced the mobility of the PMNs and markedly suppressed the generation of chemiluminiscence. UV-killed virus with intact neuraminidase produced similar effects but virus with heat-inactivated neuraminidase did not. Virus envelope-neuraminidase may be responsible for some of the effects of the virus on the PMNs.

Url:

https://api.istex.fr/ark:/67375/1BB-7W591876-B/fulltext.pdf

DOI: 10.1007/BF02019619

Affiliations:

Pays-Bas

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<term>Luminescent Measurements</term>
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<term>Mesures de luminescence</term>
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<term>Réplication virale</term>
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<term>Humains</term>
<term>Mesures de luminescence</term>
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<front><div type="abstract" xml:lang="en">Abstract: Many viral infections predispose to bacterial superinfection, and it has been suggested that the increased susceptibility to bacterial infections is at least in part due to the effect of virus on the phagocytic cell function. Since the mechanisms by which the viruses affect neutrophil function are not well understood, we studied the function of polymorphonuclear leukocytes (PMNs) after incubation with influenza virus. Phagocytosis was assayed by incubating influenza virus (strain type A-Texas-77 [H2N2]) treated leukocytes with3H-thymidine-labelled staphylococci. The oxidative metabolism of the PMNs was studied by measuring the chemiluminescence generated by virus-treated PMNs after incubation with zymosan. Chemotaxis was measured under agarose. After incubation with 107 EID50 units of influenza virus, PMNs ingested only 35 % of the bacteria, whereas control leukocytes ingested over 80 %. Influenza virus also reduced the mobility of the PMNs and markedly suppressed the generation of chemiluminiscence. UV-killed virus with intact neuraminidase produced similar effects but virus with heat-inactivated neuraminidase did not. Virus envelope-neuraminidase may be responsible for some of the effects of the virus on the PMNs.</div>
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Serveur d'exploration H2N2

Effect of influenza viras on phagocytic cells

Effect of influenza viras on phagocytic cells

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
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